Loss of ISWI ATPase SMARCA5 (SNF2H) in Acute Myeloid Leukemia Cells Inhibits Proliferation and Chromatid Cohesion

ISWI chromatin remodeling ATPase SMARCA5 (SNF2H) is a well-known factor for its role in regulation of DNA access via nucleosome sliding and assembly. SMARCA5 transcriptionally inhibits the myeloid master regulator PU.1. Upregulation of SMARCA5 was previously observed in CD34+ hematopoietic progenito...

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Bibliografske podrobnosti
izdano v:Int J Mol Sci
Main Authors: Zikmund, Tomas, Paszekova, Helena, Kokavec, Juraj, Kerbs, Paul, Thakur, Shefali, Turkova, Tereza, Tauchmanova, Petra, Greif, Philipp A., Stopka, Tomas
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2020
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7139293/
https://ncbi.nlm.nih.gov/pubmed/32197313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21062073
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