Pharmacological Inhibition of HDAC6 Attenuates NLRP3 Inflammatory Response and Protects Dopaminergic Neurons in Experimental Models of Parkinson’s Disease

AIM: To investigate the role of histone deacetylase 6 (HDAC6) deacetylation activity in nucleotide-binding oligomerization domain and leucine-rich repeat pyrin 3 domain (NLRP3) inflammatory response and explore the effects of pharmacological inhibition of HDAC6 with tubastatin A (TBA) on dopaminergi...

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Vydáno v:Front Aging Neurosci
Hlavní autoři: Yan, Shaoqi, Wei, Xinbing, Jian, Wencheng, Qin, Yue, Liu, Jia, Zhu, Shaowei, Jiang, Fan, Lou, Haiyan, Zhang, Bin
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7137996/
https://ncbi.nlm.nih.gov/pubmed/32296327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2020.00078
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