MicroRNA-153 impairs presynaptic plasticity by blocking vesicle release following chronic brain hypoperfusion

BACKGROUND: Chronic brain hypoperfusion (CBH) is closely related to Alzheimer’s disease (AD) and vascular dementia (VaD). Meanwhile, synaptic pathology plays a prominent role in the initial stage of AD and VaD. However, whether and how CBH impairs presynaptic plasticity is currently unclear. METHODS...

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Veröffentlicht in:Cell Commun Signal
Hauptverfasser: Yan, Mei-Ling, Zhang, Shuai, Zhao, Hong-Mei, Xia, Sheng-Nan, Jin, Zhuo, Xu, Yi, Yang, Lin, Qu, Yang, Huang, Si-Yu, Duan, Ming-Jing, Mao, Meng, An, Xiao-Bin, Mishra, Chandan, Zhang, Xin-Yu, Sun, Li-Hua, Ai, Jing
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7137307/
https://ncbi.nlm.nih.gov/pubmed/32252776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-00551-8
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