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ATM protein is located on presynaptic vesicles and its deficit leads to failures in synaptic plasticity

Ataxia telangiectasia is a multisystemic disorder that includes a devastating neurodegeneration phenotype. The ATM (ataxia-telangiectasia mutated) protein is well-known for its role in the DNA damage response, yet ATM is also found in association with cytoplasmic vesicular structures: endosomes and...

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Pubblicato in:J Neurophysiol
Autori principali: Vail, Graham, Cheng, Aifang, Han, Yu Ray, Zhao, Teng, Du, Shengwang, Loy, Michael M. T., Herrup, Karl, Plummer, Mark R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961758/
https://ncbi.nlm.nih.gov/pubmed/27075534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00006.2016
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