Determination of parecoxib and valdecoxib in rat plasma by UPLC-MS/MS and its application to pharmacokinetics studies

BACKGROUND: The present study aimed to develop and validate a rapid, selective, and reproducible ultra-performance liquid chromatography-tandem mass spectrometry separation method for the simultaneous determination of the levels of parecoxib and its main metabolite valdecoxib in rat plasma. Moreover...

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Vydáno v:BMC Pharmacol Toxicol
Hlavní autoři: Chen, Mengchun, Sun, Wei, Wang, Zhe, Huang, Chengke, Hu, Guoxin, Chen, Yijie, Wang, Ledan
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7137270/
https://ncbi.nlm.nih.gov/pubmed/32264977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40360-020-00406-5
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