mTOR Suppresses Macroautophagy During Striatal Postnatal Development and Is Hyperactive in Mouse Models of Autism Spectrum Disorders

Macroautophagy (hereafter referred to as autophagy) plays a critical role in neuronal function related to development and degeneration. Here, we investigated whether autophagy is developmentally regulated in the striatum, a brain region implicated in neurodevelopmental disease. We demonstrate that a...

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Dettagli Bibliografici
Pubblicato in:Front Cell Neurosci
Autori principali: Lieberman, Ori J., Cartocci, Veronica, Pigulevskiy, Irena, Molinari, Maya, Carbonell, Josep, Broseta, Miguel Bellés, Post, Michael R., Sulzer, David, Borgkvist, Anders, Santini, Emanuela
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7136750/
https://ncbi.nlm.nih.gov/pubmed/32296308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2020.00070
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