Assessment of the Role of C3(H(2)O) in the Alternative Pathway

In this study we investigate the hydrolysis of C3 to C3(H(2)O) and its ability to initiate activation via the alternative pathway (AP) of the complement system. The internal thioester bond within C3 is hydrolyzed by water in plasma because of its inherent lability. This results in the formation of n...

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Bibliografske podrobnosti
izdano v:Front Immunol
Main Authors: Fromell, Karin, Adler, Anna, Åman, Amanda, Manivel, Vivek Anand, Huang, Shan, Dührkop, Claudia, Sandholm, Kerstin, Ekdahl, Kristina N., Nilsson, Bo
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2020
Teme:
Immunology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7136553/
https://ncbi.nlm.nih.gov/pubmed/32296436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00530
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