Assessment of the Role of C3(H(2)O) in the Alternative Pathway

In this study we investigate the hydrolysis of C3 to C3(H(2)O) and its ability to initiate activation via the alternative pathway (AP) of the complement system. The internal thioester bond within C3 is hydrolyzed by water in plasma because of its inherent lability. This results in the formation of n...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Fromell, Karin, Adler, Anna, Åman, Amanda, Manivel, Vivek Anand, Huang, Shan, Dührkop, Claudia, Sandholm, Kerstin, Ekdahl, Kristina N., Nilsson, Bo
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7136553/
https://ncbi.nlm.nih.gov/pubmed/32296436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00530
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