Assessment of the Role of C3(H(2)O) in the Alternative Pathway

In this study we investigate the hydrolysis of C3 to C3(H(2)O) and its ability to initiate activation via the alternative pathway (AP) of the complement system. The internal thioester bond within C3 is hydrolyzed by water in plasma because of its inherent lability. This results in the formation of n...

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Bibliografische gegevens
Gepubliceerd in:Front Immunol
Hoofdauteurs: Fromell, Karin, Adler, Anna, Åman, Amanda, Manivel, Vivek Anand, Huang, Shan, Dührkop, Claudia, Sandholm, Kerstin, Ekdahl, Kristina N., Nilsson, Bo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2020
Onderwerpen:
Immunology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7136553/
https://ncbi.nlm.nih.gov/pubmed/32296436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00530
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