Allele-specific expression changes dynamically during T cell activation in HLA and other autoimmune loci

Genetic studies have revealed that autoimmune susceptibility variants are over-represented in memory CD4(+) T cell regulatory elements(1–3). Understanding how genetic variation affects gene expression in different T cell physiological states is essential for deciphering genetic mechanisms of autoimm...

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發表在:Nat Genet
Main Authors: Gutierrez-Arcelus, Maria, Baglaenko, Yuriy, Arora, Jatin, Hannes, Susan, Luo, Yang, Amariuta, Tiffany, Teslovich, Nikola, Rao, Deepak A., Ermann, Joerg, Jonsson, A. Helena, Navarrete, Cristina, Rich, Stephen S., Taylor, Kent D., Rotter, Jerome I., Gregersen, Peter K., Esko, Tonu, Brenner, Michael B., Raychaudhuri, Soumya
格式: Artigo
語言:Inglês
出版: 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7135372/
https://ncbi.nlm.nih.gov/pubmed/32066938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-0579-4
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