Altered Pathogenesis of a Mutant of the Murine Coronavirus MHV-A59 Is Associated with a Q159L Amino Acid Substitution in the Spike Protein()

C12, an attenuated, fusion delayed, very weakly hepatotropic mutant of mouse hepatitis virus strain A59 (MHV-A59) has been further characterized. We have previously shown that C12 has two amino acid substitutions relative to wild type virus in the spike protein, Q159L (within a region of S1 shown to...

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Enregistré dans:
Détails bibliographiques
Publié dans:Virology
Auteurs principaux: Leparc-Goffart, Isabelle, Hingley, Susan T., Chua, Ming Ming, Jiang, Xinhe, Lavi, Ehud, Weiss, Susan R.
Format: Artigo
Langue:Inglês
Publié: Academic Press. 1997
Sujets:
Regular Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7131600/
https://ncbi.nlm.nih.gov/pubmed/9426441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1006/viro.1997.8877
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