P136 Combined action of type I and type III IFN restricts initial replication of SARS-coronavirus in the lung but fails to inhibit systemic virus spread

INTRODUCTION: STAT1-deficient mice are more susceptible to infection with SARS-Coronavirus (SARS-CoV) than type I IFN receptor-deficient mice. The increased susceptibility of STAT1-deficient mice is potentially due to the lack of functional type III IFN (IFN-λ) signalling. METHODS: We used mice lack...

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Publicado no:Cytokine
Main Authors: Mahlakoiv, T., Ritz, D., Enjuanes, L., Müller, M.A., Drosten, C., Staeheli, P.
Formato: Artigo
Idioma:Inglês
Publicado em: Published by Elsevier Ltd. 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7129343/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cyto.2012.06.228
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