A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N(1)-2′O-Methylated Self RNA

The cytosolic helicase retinoic acid-inducible gene-I (RIG-I) initiates immune responses to most RNA viruses by detecting viral 5′-triphosphorylated RNA (pppRNA). Although endogenous mRNA is also 5′-triphosphorylated, backbone modifications and the 5′-ppp-linked methylguanosine ((m7)G) cap prevent i...

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Pubblicato in:Immunity
Autori principali: Schuberth-Wagner, Christine, Ludwig, Janos, Bruder, Ann Kristin, Herzner, Anna-Maria, Zillinger, Thomas, Goldeck, Marion, Schmidt, Tobias, Schmid-Burgk, Jonathan L., Kerber, Romy, Wolter, Steven, Stümpel, Jan-Philip, Roth, Andreas, Bartok, Eva, Drosten, Christian, Coch, Christoph, Hornung, Veit, Barchet, Winfried, Kümmerer, Beate M., Hartmann, Gunther, Schlee, Martin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier Inc. 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7128463/
https://ncbi.nlm.nih.gov/pubmed/26187414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.06.015
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