Combined Src/EGFR inhibition targets STAT3 signaling and induces stromal remodeling to improve survival in pancreatic cancer

Lack of durable response to cytotoxic chemotherapy is a major contributor to the dismal outcomes seen in pancreatic ductal adenocarcinoma (PDAC). Extensive tumor desmoplasia and poor vascular supply are two predominant characteristics which hinder the delivery of chemotherapeutic drugs into PDAC tum...

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Publicat a:Mol Cancer Res
Autors principals: Dosch, Austin R., Dai, Xizi, Reyzer, Michelle L., Mehra, Siddharth, Srinivasan, Supriya, Willobee, Brent A., Kwon, Deukwoo, Kashikar, Nilesh, Caprioli, Richard, Merchant, Nipun B., Nagathihalli, Nagaraj S.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7127944/
https://ncbi.nlm.nih.gov/pubmed/31949002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-0741
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