1-[2-(2-Benzoyl- and 2-benzylphenoxy)ethyl]uracils as potent anti-HIV-1 agents

Non-nucleoside reverse transcriptase inhibitors (NNRTI) are key components in highly active antiretroviral therapy for treating HIV-1. Herein we present the synthesis for a series of N1-alkylated uracil derivatives bearing ω-(2-benzyl- and 2-benzoylphenoxy)alkyl substituents as novel NNRTIs. These c...

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Bibliografiske detaljer
Udgivet i:Bioorg Med Chem
Main Authors: Novikov, Mikhail S., Ivanova, Olga N., Ivanov, Alexander V., Ozerov, Alexander A., Valuev-Elliston, Vladimir T., Temburnikar, Kartik, Gurskaya, Galina V., Kochetkov, Sergey N., Pannecouque, Christophe, Balzarini, Jan, Seley-Radtke, Katherine L.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Ltd. 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7127633/
https://ncbi.nlm.nih.gov/pubmed/21903401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.08.025
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