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cGAS and CD-NTase enzymes: structure, mechanism, and evolution
Cyclic GMP–AMP synthase (cGAS) is a signaling enzyme in human cells that controls immune-sensing of cytosolic DNA. The recent discoveries of diverse structural homologs of cGAS in animals and bacteria reveal that cGAS-like signaling is surprisingly ancient and widespread in biology. Together with th...
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| Udgivet i: | Curr Opin Struct Biol |
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| Hovedforfatter: | |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Author. Published by Elsevier Ltd.
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7127440/ https://ncbi.nlm.nih.gov/pubmed/31593902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2019.08.003 |
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