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Synthesis and biological evaluation of phosphoramidate prodrugs of two analogues of 2-deoxy-d-ribose-1-phosphate directed to the discovery of two carbasugars as new potential anti-HIV leads

2-Deoxy-α-d-ribose-1-phosphate is of great interest as it is involved in the biosynthesis and/or catabolic degradation of several nucleoside analogues of biological and therapeutic relevance. However due to the lack of a stabilising group at its 2-position, it is difficult to synthesize stable prodr...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Bioorg Med Chem
Main Authors: Hamon, Nadège, Slusarczyk, Magdalena, Serpi, Michaela, Balzarini, Jan, McGuigan, Christopher
Format: Artigo
Jezik:Inglês
Izdano: Elsevier Ltd. 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7127161/
https://ncbi.nlm.nih.gov/pubmed/25616343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.12.039
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