Design, synthesis and biological evaluation of phosphorodiamidate prodrugs of antiviral and anticancer nucleosides

We herein report the application of the phosphorodiamidate phosphate prodrug approach to a series of thirteen nucleoside analogs with antiviral or anticancer activity. Twenty-five symmetrical phosphorodiamidates were synthesized, bearing esterified l-Alanine (and in one case d-Alanine) in the prodru...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: McGuigan, Christopher, Bourdin, Claire, Derudas, Marco, Hamon, Nadège, Hinsinger, Karen, Kandil, Sahar, Madela, Karolina, Meneghesso, Silvia, Pertusati, Fabrizio, Serpi, Michaela, Slusarczyk, Magdalena, Chamberlain, Stanley, Kolykhalov, Alexander, Vernachio, John, Vanpouille, Christophe, Introini, Andrea, Margolis, Leonid, Balzarini, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Masson SAS. 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358806/
https://ncbi.nlm.nih.gov/pubmed/24177359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2013.09.047
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