Phosphoramidates of 2′-β-d-arabinouridine (AraU) as phosphate prodrugs; design, synthesis, in vitro activity and metabolism

2′-β-d-Arabinouridine (AraU), the uridine analogue of the anticancer agent AraC, was synthesized and evaluated for antiviral activity and cytotoxicity. In addition, a series of AraU monophosphate prodrugs in the form of triester phosphoramidates (ProTides) were also synthesized and tested against a...

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Vydáno v:Bioorg Med Chem
Hlavní autoři: Mehellou, Youcef, Valente, Rocco, Mottram, Huw, Walsby, Elisabeth, Mills, Kenneth I., Balzarini, Jan, McGuigan, Christopher
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier Ltd. 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7125968/
https://ncbi.nlm.nih.gov/pubmed/20299228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.02.059
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