Phosphoramidates of 2′-β-d-arabinouridine (AraU) as phosphate prodrugs; design, synthesis, in vitro activity and metabolism

2′-β-d-Arabinouridine (AraU), the uridine analogue of the anticancer agent AraC, was synthesized and evaluated for antiviral activity and cytotoxicity. In addition, a series of AraU monophosphate prodrugs in the form of triester phosphoramidates (ProTides) were also synthesized and tested against a...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Mehellou, Youcef, Valente, Rocco, Mottram, Huw, Walsby, Elisabeth, Mills, Kenneth I., Balzarini, Jan, McGuigan, Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Ltd. 2010
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7125968/
https://ncbi.nlm.nih.gov/pubmed/20299228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.02.059
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados