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Enantioselective synthesis and antiviral activity of purine and pyrimidine cyclopentenyl C-nucleosides

The enantiomerically pure carbocyclic purine and pyrimidine C-nucleosides 1–4 were synthesized via the key intermediate, 2,3-(isopropylidenedioxy)-4-(trityloxymethyl)-4-cyclopenten-1-ol (5), which was prepared from d-ribose in eight steps. Synthesized compounds were evaluated as potential antiviral...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Rao, Jagadeeshwar R., Schinazi, Raymond F., Chu, Chung K.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Ltd. 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7127144/
https://ncbi.nlm.nih.gov/pubmed/17085053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2006.10.043
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