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Synthesis and biological evaluation of nucleoside analogues having 6-chloropurine as anti-SARS-CoV agents

Nucleoside analogues that have 6-chloropurine as the nucleobase were synthesized and evaluated for anti-SARS-CoV activity by plaque reduction and yield reduction assays in order to develop novel anti-SARS-CoV agents. Among these analogues, two compounds, namely, 1 and 11, exhibited promising anti-SA...

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Bibliografski detalji
Izdano u:Bioorg Med Chem Lett
Glavni autori: Ikejiri, Masahiro, Saijo, Masayuki, Morikawa, Shigeru, Fukushi, Shuetsu, Mizutani, Tetsuya, Kurane, Ichiro, Maruyama, Tokumi
Format: Artigo
Jezik:Inglês
Izdano: Elsevier Ltd. 2007
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7126875/
https://ncbi.nlm.nih.gov/pubmed/17336519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.02.026
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