Synthesis and biological evaluation of nucleoside analogues having 6-chloropurine as anti-SARS-CoV agents

Nucleoside analogues that have 6-chloropurine as the nucleobase were synthesized and evaluated for anti-SARS-CoV activity by plaque reduction and yield reduction assays in order to develop novel anti-SARS-CoV agents. Among these analogues, two compounds, namely, 1 and 11, exhibited promising anti-SA...

Full description

Saved in:
Bibliographic Details
Published in:Bioorg Med Chem Lett
Main Authors: Ikejiri, Masahiro, Saijo, Masayuki, Morikawa, Shigeru, Fukushi, Shuetsu, Mizutani, Tetsuya, Kurane, Ichiro, Maruyama, Tokumi
Format: Artigo
Language:Inglês
Published: Elsevier Ltd. 2007
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7126875/
https://ncbi.nlm.nih.gov/pubmed/17336519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.02.026
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items