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Synthesis, cytotoxic activity, and SAR analysis of the derivatives of taxchinin A and brevifoliol
Twenty-one derivatives of taxchinin A (1) and brevifoliol (2) were synthesized and evaluated for cytotoxicity against human non-small lung cancer (A549) cell line. Nine derivatives showed potent activity with IC(50) values from 0.48 to 6.22 μM. 5-Oxo-13-TBDMS-taxchinin A (11) and 5-oxo-13,15-epoxy-1...
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| Pubblicato in: | Bioorg Med Chem |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Elsevier Ltd.
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7126827/ https://ncbi.nlm.nih.gov/pubmed/18381240 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.03.041 |
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