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Synthesis and Cytotoxicity Evaluation of Naphthalimide Derived N-Mustards

A series of N-mustards, which was conjugated to mono- or bis-naphthalimides with a flexible amine link, were synthesized and evaluated for cytotoxicity against five cancer cell lines (HCT-116, PC-3, U87 MG, Hep G2 and SK-OV-3). Several compounds displayed better activities than the control compound...

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Publicado en:Molecules
Autores principales: Lou, Qinghua, Ji, Liyan, Zhong, Wenhe, Li, Shasha, Yu, Siwang, Li, Zhongjun, Meng, Xiangbao
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6271267/
https://ncbi.nlm.nih.gov/pubmed/24968335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules19078803
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