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Barriers to and new approaches for gene therapy and gene delivery in cystic fibrosis

Clinical trials of gene therapy for cystic fibrosis suggest that current levels of gene transfer efficiency are probably too low to result in clinical benefit, largely as a result of the barriers faced by gene transfer vectors within the airways. The respiratory epithelium has evolved a complex seri...

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Bibliografiske detaljer
Udgivet i:Adv Drug Deliv Rev
Main Authors: Ferrari, Stefano, Geddes, Duncan M, Alton, Eric W.F.W
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Science B.V. 2002
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7126523/
https://ncbi.nlm.nih.gov/pubmed/12458150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0169-409X(02)00145-X
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