A DNA vaccine producing LcrV antigen in oligomers is effective in protecting mice from lethal mucosal challenge of plague

There is an urgent need to develop effective vaccines against pneumonic plague, a highly lethal and contagious disease caused by the Gram-negative bacterium Yersinia pestis. Here we demonstrate that a novel DNA vaccine expressing a modified V antigen (LcrV) of Y. pestis, with a human tissue plasmino...

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Detalhes bibliográficos
Publicado no:Vaccine
Main Authors: Wang, Shixia, Heilman, Destin, Liu, Fangjun, Giehl, Theodore, Joshi, Swati, Huang, Xiaoyun, Chou, Te-hui, Goguen, Jon, Lu, Shan
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Ltd. 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7126436/
https://ncbi.nlm.nih.gov/pubmed/15308359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2004.02.036
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