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Molecular characterization of hepatitis E virus ORF1 gene supports a papain-like cysteine protease (PCP)-domain activity
Hepatitis E Virus (HEV) ORF1 encodes the nonstructural polyprotein wherein a role of PCP-domain in ORF1 proteolysis and/or RNA replication still remains contested. A series of ORF1 mutants of HEV-SAR(55) replicon were constructed and tested for viability in S10-3 cells. Six of PCP-‘cysteine’ (C457A,...
保存先:
| 出版年: | Virus Res |
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| 第一著者: | |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Elsevier B.V.
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7125709/ https://ncbi.nlm.nih.gov/pubmed/23978667 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virusres.2013.07.020 |
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