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Molecular characterization of hepatitis E virus ORF1 gene supports a papain-like cysteine protease (PCP)-domain activity
Hepatitis E Virus (HEV) ORF1 encodes the nonstructural polyprotein wherein a role of PCP-domain in ORF1 proteolysis and/or RNA replication still remains contested. A series of ORF1 mutants of HEV-SAR(55) replicon were constructed and tested for viability in S10-3 cells. Six of PCP-‘cysteine’ (C457A,...
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| Veröffentlicht in: | Virus Res |
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| 1. Verfasser: | |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Elsevier B.V.
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7125709/ https://ncbi.nlm.nih.gov/pubmed/23978667 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virusres.2013.07.020 |
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