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Heparin enhances the furin cleavage of HIV‐1 gp160 peptides
Infectious HIV‐1 requires gp160 cleavage by furin at the REKR(511)↓ motif (site1) into the gp120/gp41 complex, whereas the KAKR(503) (site2) sequence remains uncleaved. We synthesized 41mer and 51mer peptides, comprising site1 and site2, to study their conformation and in vitro furin processing. We...
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| Publicado en: | FEBS Lett |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2007
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7125586/ https://ncbi.nlm.nih.gov/pubmed/18037384 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2007.11.050 |
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