Fast degrading polyesters as siRNA nano-carriers for pulmonary gene therapy

A potential siRNA carrier for pulmonary gene delivery was assessed by encapsulating siRNA into biodegradable polyester nanoparticles consisting of tertiary-amine-modified polyvinyl alcohol (PVA) backbones grafted to poly(d,l-lactide-co-glycolide) (PLGA). The resulting siRNA nanoparticles were prepar...

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Bibliographic Details
Published in:J Control Release
Main Authors: Nguyen, Juliane, Steele, Terry W.J., Merkel, Olivia, Reul, Regina, Kissel, Thomas
Format: Artigo
Language:Inglês
Published: Elsevier B.V. 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7125568/
https://ncbi.nlm.nih.gov/pubmed/18619502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2008.06.010
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