NPM1 upregulates the transcription of PD-L1 and suppresses T cell activity in triple-negative breast cancer

Programmed cell death protein-1 (PD-1)/programmed cell death ligand-1 (PD-L1) interaction plays a crucial role in tumor-associated immune escape. Here, we verify that triple-negative breast cancer (TNBC) has higher PD-L1 expression than other subtypes. We then discover that nucleophosmin (NPM1) bind...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Qin, Ge, Wang, Xin, Ye, Shubiao, Li, Yizhuo, Chen, Miao, Wang, Shusen, Qin, Tao, Zhang, Changlin, Li, Yixin, Long, Qian, Hu, Huabin, Shi, Dingbo, Li, Jiaping, Zhang, Kai, Zhai, Qinglian, Tang, Yanlai, Kang, Tiebang, Lan, Ping, Xie, Fangyun, Lu, Jianjun, Deng, Wuguo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7125142/
https://ncbi.nlm.nih.gov/pubmed/32245950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15364-z
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