Mutated CEACAMs Disrupt Transforming Growth Factor beta Signaling and Alter the Intestinal Microbiome to Promote Colorectal Carcinogenesis

BACKGROUND AND AIMS: We studied interactions among proteins of the carcinoembryonic antigen related cell adhesion molecule (CEACAM) family, which interact with microbes, and transforming growth factor beta (TGFB) signaling pathway, which is often altered in colorectal cancer cells. We investigated m...

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Pubblicato in:Gastroenterology
Autori principali: Gu, Shoujun, Zaidi, Sobia, Hassan, Imtaiyaz, Mohammad, Taj, Malta, Tathiane M., Noushmehr, Houtan, Nguyen, Bryan, Crandall, Keith A., Srivastav, Jigisha, Obias, Vincent, Lin, Paul, Nguyen, Bao-Ngoc, Yao, Michael, Yao, Ren, King, Charles Hadley, Mazumder, Raja, Mishra, Bibhuti, Rao, Shuyun, Mishra, Lopa
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7124154/
https://ncbi.nlm.nih.gov/pubmed/31585122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2019.09.023
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