Catalytic Deuterium Incorporation within Metabolically Stable β-Amino C─H Bonds of Drug Molecules

An efficient deuteration process of β-amino C─H bonds in various N-alkylamine-based pharmaceutical compounds has been developed. Catalytic reactions begin with the action of Lewis acidic B(C(6)F(5))(3) and Brønsted basic N-alkylamine, converting a drug molecule into the corresponding enamine. The ac...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Chang, Yejin, Yesilcimen, Ahmet, Cao, Min, Zhang, Yuyang, Zhang, Bochao, Chan, Jessica Z., Wasa, Masayuki
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7123439/
https://ncbi.nlm.nih.gov/pubmed/31480842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b08662
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