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Catalytic Deuterium Incorporation within Metabolically Stable β-Amino C─H Bonds of Drug Molecules
An efficient deuteration process of β-amino C─H bonds in various N-alkylamine-based pharmaceutical compounds has been developed. Catalytic reactions begin with the action of Lewis acidic B(C(6)F(5))(3) and Brønsted basic N-alkylamine, converting a drug molecule into the corresponding enamine. The ac...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7123439/ https://ncbi.nlm.nih.gov/pubmed/31480842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b08662 |
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