Inhibition of hepatitis B virus replication by ligand-mediated activation of RNase L

RNase L is a cellular endoribonuclease that is activated by 2′,5′-linked oligoadenylates (2–5A), which are unique and specific ligands synthesized by a family of interferon-inducible, dsRNA-activated enzymes named oligoadenylate synthetases. In the typical antiviral pathway, activated RNase L degrad...

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Gepubliceerd in:Antiviral Res
Hoofdauteurs: Park, Il-Hyun, Kwon, Young-Chan, Ryu, Wang-Shick, Ahn, Byung-Yoon
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier B.V. 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7119188/
https://ncbi.nlm.nih.gov/pubmed/24509240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2014.01.021
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