Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors

N-Substituted isatin derivatives were prepared from the reaction of isatin and various bromides via two steps. Bioactivity assay results (in vitro tests) demonstrated that some of these compounds are potent and selective inhibitors against SARS coronavirus 3CL protease with IC(50) values ranging fro...

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Pubblicato in:Bioorg Med Chem Lett
Autori principali: Chen, Li-Rung, Wang, Yu-Chin, Lin, Yi Wen, Chou, Shan-Yen, Chen, Shyh-Fong, Liu, Lee Tai, Wu, Ying-Ta, Kuo, Chih-Jung, Chen, Tom Shieh-Shung, Juang, Shin-Hun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier Ltd. 2005
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7119080/
https://ncbi.nlm.nih.gov/pubmed/15896959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2005.04.027
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