Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors

N-Substituted isatin derivatives were prepared from the reaction of isatin and various bromides via two steps. Bioactivity assay results (in vitro tests) demonstrated that some of these compounds are potent and selective inhibitors against SARS coronavirus 3CL protease with IC(50) values ranging fro...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Chen, Li-Rung, Wang, Yu-Chin, Lin, Yi Wen, Chou, Shan-Yen, Chen, Shyh-Fong, Liu, Lee Tai, Wu, Ying-Ta, Kuo, Chih-Jung, Chen, Tom Shieh-Shung, Juang, Shin-Hun
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Ltd. 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7119080/
https://ncbi.nlm.nih.gov/pubmed/15896959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2005.04.027
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