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Discovering novel chemical inhibitors of human cyclophilin A: Virtual screening, synthesis, and bioassay
Cyclophilin A (CypA) is a member of cyclophilins, a family of the highly homologous peptidyl prolyl cis–trans isomerases (PPIases), which can bind to cyclosporin A (CsA). CypA plays critical roles in various biological processes, including protein folding, assembly, transportation, regulation of neu...
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| Publicado en: | Bioorg Med Chem |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Elsevier Ltd.
2006
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7119052/ https://ncbi.nlm.nih.gov/pubmed/16307882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2005.11.006 |
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