MERS coronavirus nsp1 participates in an efficient propagation through a specific interaction with viral RNA

MERS-CoV is the only lethal human CoV still endemic in the Arabian Peninsula and neither vaccine nor therapeutics against MERS-CoV infection is available. The nsp1 of CoV is thought to be a major virulence factor because it suppresses protein synthesis through the degradation of host mRNA. In contra...

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Vydáno v:Virology
Hlavní autoři: Terada, Yutaka, Kawachi, Kengo, Matsuura, Yoshiharu, Kamitani, Wataru
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier Inc. 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7118922/
https://ncbi.nlm.nih.gov/pubmed/28843094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2017.08.026
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