4β-Hydroxycholesterol Signals From the Liver to Regulate Peripheral Cholesterol Transporters

Activation of pregnane X receptor (PXR) elevates circulating 4β-hydroxycholesterol (4βHC), an agonist of liver X receptor (LXR). PXR may also regulate 25-hydroxycholesterol and 27-hydroxycholesterol. Our aim was to elucidate the roles of PXR and oxysterols in the regulation of cholesterol transporte...

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Publicado en:Front Pharmacol
Main Authors: Salonurmi, Tuire, Nabil, Heba, Ronkainen, Justiina, Hyötyläinen, Tuulia, Hautajärvi, Heidi, Savolainen, Markku J., Tolonen, Ari, Orešič, Matej, Känsäkoski, Päivi, Rysä, Jaana, Hakkola, Jukka, Hukkanen, Janne
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2020
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7118195/
https://ncbi.nlm.nih.gov/pubmed/32292343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00361
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