Screening and characterization of a diverse panel of metagenomic imine reductases for biocatalytic reductive amination

Finding faster and simpler ways to screen protein sequence space to enable the identification of new biocatalysts for asymmetric synthesis remains both a challenge and a rate-limiting step in enzyme discovery. Biocatalytic strategies for the synthesis of chiral amines are increasingly attractive and...

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Publicado no:Nat Chem
Principais autores: Marshall, James R., Yao, Peiyuan, Montgomery, Sarah L., Finnigan, James D., Thorpe, Thomas W., Palmer, Ryan B., Mangas-Sanchez, Juan, Duncan, Richard A. M., Heath, Rachel S., Graham, Kirsty M., Cook, Darren J., Charnock, Simon J., Turner, Nicholas J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116802/
https://ncbi.nlm.nih.gov/pubmed/33380742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-020-00606-w
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