Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms

Acetaldehyde is a highly reactive, DNA damaging metabolite, produced upon alcohol consumption(1). Impaired acetaldehyde detoxification is common in the Asian population, and is associated with alcohol related cancers(1,2). Cellular protection against acetaldehyde-induced damage is provided by DNA cr...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Hodskinson, Michael R., Bolner, Alice, Sato, Koichi, Kamimae-Lanning, Ashley N., Rooijers, Koos, Witte, Merlijn, Mahesh, Mohan, Silhan, Jan, Petek, Maya, Williams, David M., Kind, Jop, Chin, Jason, Patel, Ketan J., Knipscheer, Puck
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116288/
https://ncbi.nlm.nih.gov/pubmed/32132710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2059-5
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