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Discovery and evolution of RNA and XNA reverse transcriptase function and fidelity
The ability of reverse transcriptases (RTs) to synthesize a complementary DNA (cDNA) from natural RNA and a range of unnatural xeno nucleic acid (XNA) template chemistries, underpins key methods in molecular and synthetic genetics. However, RTs have proven challenging to discover and engineer, in pa...
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| Udgivet i: | Nat Chem |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7116287/ https://ncbi.nlm.nih.gov/pubmed/32690899 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-020-0502-8 |
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