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Encoded synthesis and evolution of alkyl-phosphonate nucleic acids: a synthetic genetic polymer with an uncharged backbone chemistry

The physicochemical properties of nucleic acids are dominated by their highly charged phosphodiester backbone chemistry. The polyelectrolyte structure decouples information content (base sequence) from bulk properties such as solubility and has been proposed as a defining trait of all informational...

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Detalles Bibliográficos
Publicado en:Nat Chem
Main Authors: Arangundy-Franklin, Sebastian, Taylor, Alexander I., Porebski, Benjamin T., Genna, Vito, Peak-Chew, Sew, Vaisman, Alexandra, Woodgate, Roger, Orozco, Modesto, Holliger, Philipp
Formato: Artigo
Idioma:Inglês
Publicado: 2019
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542681/
https://ncbi.nlm.nih.gov/pubmed/31011171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-019-0255-4
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