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Encoded synthesis and evolution of alkyl-phosphonate nucleic acids: a synthetic genetic polymer with an uncharged backbone chemistry

The physicochemical properties of nucleic acids are dominated by their highly charged phosphodiester backbone chemistry. The polyelectrolyte structure decouples information content (base sequence) from bulk properties such as solubility and has been proposed as a defining trait of all informational...

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Détails bibliographiques
Publié dans:Nat Chem
Auteurs principaux: Arangundy-Franklin, Sebastian, Taylor, Alexander I., Porebski, Benjamin T., Genna, Vito, Peak-Chew, Sew, Vaisman, Alexandra, Woodgate, Roger, Orozco, Modesto, Holliger, Philipp
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542681/
https://ncbi.nlm.nih.gov/pubmed/31011171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-019-0255-4
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