CDK6 is an essential direct target of NUP98-fusion proteins in acute myeloid leukemia

Fusion proteins involving Nucleoporin 98 (NUP98) are recurrently found in acute myeloid leukemia (AML) and are associated with poor prognosis. Lack of mechanistic insight into NUP98-fusion-dependent oncogenic transformation has so far precluded the development of rational targeted therapies. We reas...

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Published in:Blood
Main Authors: Schmoellerl, Johannes, Barbosa, Inês Amorim Monteiro, Eder, Thomas, Brandstoetter, Tania, Schmidt, Luisa, Maurer, Barbara, Troester, Selina, Pham, Ha Thi Thanh, Sagarajit, Mohanty, Ebner, Jessica, Manhart, Gabriele, Aslan, Ezgi, Terlecki-Zaniewicz, Stefan, Van der Veen, Christa, Hoermann, Gregor, Duployez, Nicolas, Petit, Arnaud, Lapillonne, Helene, Puissant, Alexandre, Itzykson, Raphael, Moriggl, Richard, Heuser, Michael, Meisel, Roland, Valent, Peter, Sexl, Veronika, Zuber, Johannes, Grebien, Florian
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7115844/
https://ncbi.nlm.nih.gov/pubmed/32344427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019003267
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