Targeted Inhibition of the NUP98-NSD1 Fusion Oncogene in Acute Myeloid Leukemia

SIMPLE SUMMARY: NUP98-NSD1-positive acute myeloid leukemia (AML) frequently shows an additional mutation in Neuroblastoma rat sarcoma (NRAS). However, the synergistic effect of NUP98-NSD1 and NRASG12D in leukemic transformation remained unclear. In addition, NUP98-NSD1 positive AML patients respond...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Mohanty, Sagarajit, Jyotsana, Nidhi, Sharma, Amit, Kloos, Arnold, Gabdoulline, Razif, Othman, Basem, Lai, Courteney K., Schottmann, Renate, Mandhania, Madhvi, Schmoellerl, Johannes, Grebien, Florian, Ramsay, Euan, Thomas, Anitha, Vornlocher, Hans-Peter, Ganser, Arnold, Thol, Felicitas, Heuser, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7600396/
https://ncbi.nlm.nih.gov/pubmed/32993115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12102766
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