Acyclic nucleoside thiophosphonates as potent inhibitors of HIV and HBV replication

9-[2-(Thiophosphonomethoxy)ethyl]adenine 3 and (R)-9-[2-(Thiophosphonomethoxy)propyl]adenine 4 were synthesized as the first thiophosphonate nucleosides bearing a sulfur atom at the α-position of the acyclic nucleoside phosphonates PMEA and PMPA. Thiophosphonates S-PMEA 3 and S-PMPA 4 were evaluated...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Barral, Karine, Weck, Clément, Payrot, Nadine, Roux, Loic, Durafour, Céline, Zoulim, Fabien, Neyts, Johan, Balzarini, Jan, Canard, Bruno, Priet, Stéphane, Alvarez, Karine
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Masson SAS. 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7115536/
https://ncbi.nlm.nih.gov/pubmed/21803462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2011.06.034
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