2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure–activity relationship and mode of action studies

2-Aminopyrimidine based 4-aminoquinolines were synthesized using an efficacious protocol. Some of the compounds showed in vitro anti-plasmodial activity against drug-sensitive CQ(S) (3D7) and drug-resistant CQ(R) (K1) strains of Plasmodium falciparum in the nM range. In particular, 5-isopropyloxycar...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Singh, Kamaljit, Kaur, Hardeep, Chibale, Kelly, Balzarini, Jan, Little, Susan, Bharatam, Prasad V.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Masson SAS. Published by Elsevier Masson SAS 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7115513/
https://ncbi.nlm.nih.gov/pubmed/22459876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2012.03.007
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