Lactococcus lactis-expressing listeriolysin O (LLO) provides protection and specific CD8(+) T cells against Listeria monocytogenes in the murine infection model

Lactococcus lactis has previously been proposed as a vaccine platform for the safe delivery of heterologous antigens. Here we utilized L. lactis as a live vector for expression of listeriolysin O (LLO), a major Listeria monocytogenes antigen and virulence factor. A variety of plasmid constructs were...

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Detalhes bibliográficos
Publicado no:Vaccine
Main Authors: Bahey-El-Din, Mohammed, Casey, Pat G., Griffin, Brendan T., Gahan, Cormac G.M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Ltd. 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7115502/
https://ncbi.nlm.nih.gov/pubmed/18691625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2008.07.047
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